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RPA2 antibody (N-Term)

RPA2 Reactivity: Human, Mouse WB, IHC, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6264708
  • Target See all RPA2 Antibodies
    RPA2 (Replication Protein A2, 32kDa (RPA2))
    Binding Specificity
    • 36
    • 15
    • 7
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 99
    • 73
    • 48
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 112
    • 18
    • 2
    • 1
    Rabbit
    Clonality
    • 104
    • 29
    Polyclonal
    Conjugate
    • 75
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This RPA2 antibody is un-conjugated
    Application
    • 105
    • 39
    • 38
    • 28
    • 26
    • 25
    • 23
    • 19
    • 9
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    RPA32/RPA2 Antibody detects endogenous levels of total RPA32/RPA2.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Sheep,Dog,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human RPA32/RPA2, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product RPA2 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    RPA2 (Replication Protein A2, 32kDa (RPA2))
    Alternative Name
    RPA2 (RPA2 Products)
    Synonyms
    REPA2 antibody, RPA32 antibody, 153194_at antibody, CG9273 antibody, Dmel\\CG9273 antibody, dRPA2 antibody, rpa antibody, zgc:109822 antibody, ik:tdsubc_2g1 antibody, xx:tdsubc_2g1 antibody, repa2 antibody, rpa32 antibody, RPA2 antibody, GB13976 antibody, LOC100230445 antibody, AA409079 antibody, AI325195 antibody, AU020965 antibody, RPA34 antibody, Rf-A2 antibody, replication protein A2 antibody, Replication protein A2 antibody, replication protein A2, 32kDa antibody, replication protein A 32 kDa subunit antibody, RPA2 antibody, Rpa2 antibody, rpa2 antibody, LOC725418 antibody, RPA2_2 antibody
    Background

    Description: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.

    Gene: RPA2

    Molecular Weight
    32kDa
    Gene ID
    6118
    UniProt
    P15927
    Pathways
    Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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