RAB43 antibody (Internal Region)

Catalog No. ABIN6264583

Product Details anti-RAB43 Antibody

Target: RAB43 (RAB43, Member RAS Oncogene Family (RAB43))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB43 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: RAB43 Antibody detects endogenous levels of total RAB43.

Predicted Reactivity: Pig,Horse

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RAB43, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for RAB43

Target: RAB43 (RAB43, Member RAS Oncogene Family (RAB43))

Alternative Name: RAB43 (RAB43 Products)

Synonyms: rab43 antibody, fi21h07 antibody, wu:fi21h07 antibody, zgc:136785 antibody, RAB11B antibody, RAB41 antibody, 1810048P08Rik antibody, 2500004H21Rik antibody, AW490415 antibody, RAB43, member RAS oncogene family antibody, ISY1 splicing factor homolog antibody, RAB43 antibody, rab43 antibody, isy1 antibody, Rab43 antibody

Background:

Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Gene: RAB43

Molecular Weight: 23 kDa

Gene ID: 339122

UniProt: Q86YS6