RAB11B antibody (C-Term)

Catalog No. ABIN6264548

Product Details anti-RAB11B Antibody

Target: RAB11B (RAB11B, Member RAS Oncogene Family (RAB11B))

Binding Specificity: C-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB11B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: Rab11B Antibody detects endogenous levels of total Rab11B.

Predicted Reactivity: Pig,Bovine,Sheep,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Rab11B, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for RAB11B

Target: RAB11B (RAB11B, Member RAS Oncogene Family (RAB11B))

Alternative Name: RAB11B (RAB11B Products)

Synonyms: zgc:92772 antibody, H-YPT3 antibody, A730055L17Rik antibody, rab11b antibody, wu:fb07g11 antibody, zgc:55760 antibody, RAB11B, member RAS oncogene family, b antibody, RAB11B, member RAS oncogene family antibody, RAB11B, member RAS oncogene family, a antibody, RAB11B, member RAS oncogene family, gene 1 S homeolog antibody, rab11bb antibody, RAB11B antibody, Rab11b antibody, rab11ba antibody, rab11b.1.S antibody

Background:

Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.

Gene: RAB11B

Molecular Weight: 28kDa

Gene ID: 9230

UniProt: Q15907

Pathways: Hormone Transport, Carbohydrate Homeostasis