PREX1 antibody (Internal Region)

Catalog No. ABIN6264416

Product Details anti-PREX1 Antibody

Target: PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 (PREX1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PREX1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: PREX1 Antibody detects endogenous levels of total PREX1.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PREX1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for PREX1

Target: PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 (PREX1))

Alternative Name: PREX1 (PREX1 Products)

Synonyms: MGC68772 antibody, P-REX1 antibody, G630042G04 antibody, Setd6 antibody, RGD1306534 antibody, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 L homeolog antibody, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 antibody, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 antibody, prex1.L antibody, PREX1 antibody, prex1 antibody, Prex1 antibody

Background:

Description: Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

Gene: PREX1

Molecular Weight: 186 kDa

Gene ID: 57580

UniProt: Q8TCU6

Pathways: Regulation of Actin Filament Polymerization