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PRC1 antibody (Internal Region)

PRC1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6264405
  • Target See all PRC1 Antibodies
    PRC1 (Protein Regulator of Cytokinesis 1 (PRC1))
    Binding Specificity
    • 8
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    Human, Mouse, Rat
    Host
    • 22
    • 3
    Rabbit
    Clonality
    • 22
    • 3
    Polyclonal
    Conjugate
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This PRC1 antibody is un-conjugated
    Application
    • 11
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    PRC1 Antibody detects endogenous levels of total PRC1.
    Predicted Reactivity
    Pig,Horse,Sheep,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human PRC1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product PRC1 Primary Antibody
  • Application Notes
    WB 1:1000-3000, IHC 1:200, IF/ICC, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    PRC1 (Protein Regulator of Cytokinesis 1 (PRC1))
    Alternative Name
    PRC1 (PRC1 Products)
    Synonyms
    cb212 antibody, prc1 antibody, prc1l antibody, zgc:55982 antibody, zgc:86918 antibody, MGC68845 antibody, zgc:55664 antibody, ase1 antibody, ASE1 antibody, D7Ertd348e antibody, protein regulator of cytokinesis 1 antibody, protein regulator of cytokinesis 1a antibody, protein regulator of cytokinesis 1 S homeolog antibody, protein regulator of cytokinesis 1b antibody, PRC1 antibody, prc1a antibody, prc1.S antibody, prc1b antibody, CNC07120 antibody, prc1 antibody, Prc1 antibody
    Background

    Description: Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).

    Gene: PRC1

    Molecular Weight
    72kDa
    Gene ID
    9055
    UniProt
    O43663
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