PPP1CA antibody (C-Term)
-
- Target See all PPP1CA Antibodies
- PPP1CA (Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA))
-
Binding Specificity
- C-Term
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This PPP1CA antibody is un-conjugated
-
Application
- Western Blotting (WB), ELISA
- Specificity
- PPP1CA Antibody detects endogenous levels of total PPP1CA.
- Predicted Reactivity
- Bovine,Horse,Sheep,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human PPP1CA, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product PPP1CA Primary Antibody
-
-
- Application Notes
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
-
- Target
- PPP1CA (Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA))
- Alternative Name
- PPP1CA (PPP1CA Products)
- Synonyms
- PP-1A antibody, PP1A antibody, PP1alpha antibody, PPP1A antibody, Ppp1c antibody, dism2 antibody, ppp1a antibody, wu:fc04c08 antibody, wu:fc09b07 antibody, wu:fc30g11 antibody, wu:fe05h08 antibody, zgc:85729 antibody, Ppp1ca antibody, fb18b03 antibody, fd20h04 antibody, wu:fb18b03 antibody, wu:fd20h04 antibody, wu:fl22a03 antibody, zgc:55744 antibody, zgc:76940 antibody, protein phosphatase 1 catalytic subunit alpha antibody, protein phosphatase 1, catalytic subunit, alpha isoform antibody, protein phosphatase 1, catalytic subunit, alpha isozyme L homeolog antibody, protein phosphatase 1, catalytic subunit, alpha isozyme antibody, protein phosphatase 1, catalytic subunit, alpha isozyme a antibody, protein phosphatase 1, catalytic subunit, alpha isozyme b antibody, PPP1CA antibody, Ppp1ca antibody, ppp1ca.L antibody, ppp1ca antibody, ppp1caa antibody, ppp1cab antibody
- Background
-
Description: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).
Gene: PPP1CA
- Molecular Weight
- 38kDa
- Gene ID
- 5499
- UniProt
- P62136
- Pathways
- M Phase, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Lipid Metabolism
-