PHF19 antibody (Internal Region)
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- Target See all PHF19 Antibodies
- PHF19 (PHD Finger Protein 19 (PHF19))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PHF19 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificity
- PHF19 Antibody detects endogenous levels of total PHF19.
- Predicted Reactivity
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human PHF19, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product PHF19 Primary Antibody
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- PHF19 (PHD Finger Protein 19 (PHF19))
- Alternative Name
- PHF19 (PHF19 Products)
- Synonyms
- si:dkeyp-51b7.1 antibody, pcl3 antibody, MGC147603 antibody, MTF2L1 antibody, PCL3 antibody, TDRD19B antibody, 3110009G19Rik antibody, 3321402G02Rik antibody, PHD finger protein 19 antibody, Phf19 antibody, PHF19 antibody, phf19 antibody
- Background
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Description: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
Gene: PHF19
- Molecular Weight
- 66 kDa
- Gene ID
- 26147
- UniProt
- Q5T6S3
- Pathways
- Stem Cell Maintenance
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