OBFC2A antibody (Internal Region)

Catalog No. ABIN6263791

Product Details anti-OBFC2A Antibody

Target: OBFC2A (Oligonucleotide/oligosaccharide-Binding Fold Containing 2A (OBFC2A))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OBFC2A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: OBFC2A Antibody detects endogenous levels of total OBFC2A.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human OBFC2A, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for OBFC2A

Target: OBFC2A (Oligonucleotide/oligosaccharide-Binding Fold Containing 2A (OBFC2A))

Alternative Name: NABP1 (OBFC2A Products)

Synonyms: OBFC2A antibody, SOSS-B2 antibody, SSB2 antibody, 4930434H03Rik antibody, 4930442A21Rik antibody, 4930488J04Rik antibody, 4933440J18Rik antibody, 5830411E10Rik antibody, AI852561 antibody, Nbp1 antibody, Obfc2a antibody, Ssb2 antibody, RGD1306658 antibody, nucleic acid binding protein 1 antibody, NABP1 antibody, Nabp1 antibody

Background:

Description: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Gene: NABP1

Molecular Weight: 22 kDa

Gene ID: 64859

UniProt: Q96AH0