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NUAK1 antibody (C-Term)

NUAK1 Reactivity: Human, Mouse, Rat ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6263759
  • Target See all NUAK1 Antibodies
    NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))
    Binding Specificity
    • 15
    • 8
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 56
    • 26
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 52
    • 4
    • 1
    Rabbit
    Clonality
    • 56
    • 1
    Polyclonal
    Conjugate
    • 22
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NUAK1 antibody is un-conjugated
    Application
    • 27
    • 24
    • 18
    • 13
    • 13
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Specificity
    NuaK1 Antibody detects endogenous levels of total NuaK1.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human NuaK1, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product NUAK1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))
    Alternative Name
    NUAK1 (NUAK1 Products)
    Synonyms
    ARK5 antibody, AU014801 antibody, AW494241 antibody, B230104P22Rik antibody, Omphk1 antibody, NUAK family kinase 1 antibody, NUAK family, SNF1-like kinase, 1 antibody, NUAK1 antibody, Nuak1 antibody
    Background

    Description: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).

    Gene: NUAK1

    Molecular Weight
    75kDa
    Gene ID
    9891
    UniProt
    O60285
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