GRIN2C antibody (Internal Region)
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- Target See all GRIN2C Antibodies
- GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))
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Binding Specificity
- Internal Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GRIN2C antibody is un-conjugated
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Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
- Specificity
- NMDA epsilon 3 Antibody detects endogenous levels of total NMDA epsilon 3.
- Predicted Reactivity
- Pig,Bovine,Sheep,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human NMDA epsilon 3, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product GRIN2C Primary Antibody
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- Application Notes
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))
- Alternative Name
- GRIN2C (GRIN2C Products)
- Synonyms
- GRIN2C antibody, NMDAR2C antibody, il12rb2l antibody, il-12rb2.b antibody, nr2c antibody, GluN2C antibody, NR2C antibody, glutamate ionotropic receptor NMDA type subunit 2C antibody, interleukin 12 receptor, beta 2a, like antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 2C S homeolog antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 2C antibody, glutamate receptor, ionotropic, NMDA2C (epsilon 3) antibody, GRIN2C antibody, il12rb2l antibody, grin2c.S antibody, grin2c antibody, Grin2c antibody
- Background
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Description: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:26875626). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).
Gene: GRIN2C
- Molecular Weight
- 134 kDa
- Gene ID
- 2905
- UniProt
- Q14957
- Pathways
- Synaptic Membrane
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