NDE1 antibody (N-Term)

Catalog No. ABIN6263549

Product Details anti-NDE1 Antibody

Target: NDE1

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NDE1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: NDE1 Antibody detects endogenous levels of total NDE1.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NDE1, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for NDE1

Target: NDE1

Alternative Name: NDE1 (NDE1 Products)

Synonyms: 2810027M15Rik antibody, AU042936 antibody, AW822251 antibody, Nude antibody, mNudE antibody, HOM-TES-87 antibody, LIS4 antibody, NDE antibody, NUDE antibody, NUDE1 antibody, fb82g01 antibody, im:7141877 antibody, wu:fb82g01 antibody, zgc:114109 antibody, nudE neurodevelopment protein 1 antibody, Nde1 antibody, NDE1 antibody, nde1 antibody

Background:

Description: Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.

Gene: NDE1

Molecular Weight: 40 kDa

Gene ID: 54820

UniProt: Q9NXR1