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Myosin XVIIIA antibody (Internal Region)

MYO18A Reactivity: Human, Rat, Mouse WB, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6263478
  • Target See all Myosin XVIIIA (MYO18A) Antibodies
    Myosin XVIIIA (MYO18A)
    Binding Specificity
    • 4
    • 2
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    Human, Rat, Mouse
    Host
    • 11
    Rabbit
    Clonality
    • 11
    Polyclonal
    Conjugate
    • 8
    • 1
    • 1
    • 1
    This Myosin XVIIIA antibody is un-conjugated
    Application
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    MYO18A Antibody detects endogenous levels of total MYO18A.
    Predicted Reactivity
    Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human MYO18A, corresponding to a region within the internal amino acids.
    Isotype
    IgG
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    Myosin XVIIIA (MYO18A)
    Alternative Name
    MYO18A (MYO18A Products)
    Synonyms
    myosin-18 antibody, MYSPDZ antibody, SPR210 antibody, MyoPDZ antibody, MysPDZ antibody, myosin XVIIIa antibody, myosin XVIIIA antibody, unconventional myosin-XVIIIa antibody, myosin XVIIIA L homeolog antibody, Myosin XVIIIA antibody, myosin xviiia antibody, Myo18a antibody, MYO18A antibody, myo18a antibody, LOC100183025 antibody, myo18a.L antibody, LOC100640961 antibody, Bm1_54460 antibody, LOAG_04825 antibody
    Background

    Description: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939).

    Gene: MYO18A

    Molecular Weight
    230 kDa,190 kDa
    Gene ID
    399687
    UniProt
    Q92614
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