MORF4L1 antibody (N-Term)

Catalog No. ABIN6263328

Product Details anti-MORF4L1 Antibody

Target: MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MORF4L1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: MORF4L1 Antibody detects endogenous levels of total MORF4L1.

Predicted Reactivity: Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MORF4L1, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for MORF4L1

Target: MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))

Alternative Name: MORF4L1 (MORF4L1 Products)

Synonyms: Eaf3 antibody, HsT17725 antibody, MEAF3 antibody, MORFRG15 antibody, MRG15 antibody, S863-6 antibody, TEG-189 antibody, Tex189 antibody, mKIAA4002 antibody, MORF4L2 antibody, CG6363 antibody, DmMRG15 antibody, Dmel\\CG6363 antibody, Dmrg15 antibody, Mrg15 antibody, dMRG15 antibody, dMrg15 antibody, l(3)j6A3 antibody, zgc:92289 antibody, mortality factor 4 like 1 antibody, MORF-related gene 15 antibody, MRG15 antibody, mortality factor 4 like 1 S homeolog antibody, MORF4L1 antibody, Morf4l1 antibody, MRG15 antibody, CpipJ_CPIJ013367 antibody, morf4l1.S antibody, morf4l1 antibody

Background:

Description: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.

Gene: MORF4L1

Molecular Weight: 41kDa

Gene ID: 10933

UniProt: Q9UBU8

Pathways: Chromatin Binding