MESDC2 antibody (Internal Region)

Catalog No. ABIN6263227

Product Details anti-MESDC2 Antibody

Target: MESDC2 (Mesoderm Development Candidate 2 (MESDC2))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MESDC2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: MESDC2 Antibody detects endogenous levels of total MESDC2.

Predicted Reactivity: Zebrafish,Bovine,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MESDC2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for MESDC2

Target: MESDC2 (Mesoderm Development Candidate 2 (MESDC2))

Alternative Name: MESDC2 (MESDC2 Products)

Synonyms: MGC115616 antibody, MESDC2 antibody, BOCA antibody, MESD antibody, 2210015O11Rik antibody, AW537813 antibody, mKIAA0081 antibody, mesd antibody, msd antibody, zgc:158636 antibody, mesoderm development LRP chaperone antibody, mesoderm development LRP chaperone L homeolog antibody, mesoderm development candidate 2 antibody, MESD antibody, mesd.L antibody, CpipJ_CPIJ010816 antibody, Tsp_04045 antibody, mesd antibody, Mesd antibody, MESDC2 antibody

Background:

Description: Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity).

Gene: MESDC2

Molecular Weight: 26 kDa

Gene ID: 23184

UniProt: Q14696