MBD1 antibody (C-Term)
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- Target See all MBD1 Antibodies
- MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))
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Binding Specificity
- C-Term
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MBD1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- MBD1 Antibody detects endogenous levels of total MBD1.
- Predicted Reactivity
- Pig,Horse,Sheep,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human MBD1, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product MBD1 Primary Antibody
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anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (AA 415-508) antibody
MBD1 Reactivity: Human WB, ELISA, IHC (p) Host: Mouse Monoclonal 2C7 unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (AA 415-508) antibodyMBD1 Reactivity: Human WB, ELISA, IF Host: Mouse Monoclonal 4F6 unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (AA 1-605) antibodyMBD1 Reactivity: Human WB, IF Host: Mouse Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (AA 106-355) antibodyMBD1 Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (AA 376-405), (C-Term) antibodyMBD1 Reactivity: Human WB Host: Rabbit Polyclonal RB2371 unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (C-Term) antibodyMBD1 Reactivity: Human, Rat, Dog, Rabbit, Cow, Guinea Pig, Horse, Mouse, Monkey, Bat, Pig WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (C-Term) antibodyMBD1 Reactivity: Human, Rat, Dog, Rabbit, Cow, Guinea Pig, Horse WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (N-Term) antibodyMBD1 Reactivity: Human WB, ELISA, ChIP Host: Rabbit Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (AA 391-405) antibodyMBD1 Reactivity: Human, Monkey WB Host: Mouse Monoclonal 100B272-1- unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (AA 98-113) antibodyMBD1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))
- Alternative Name
- MBD1 (MBD1 Products)
- Synonyms
- CXXC3 antibody, PCM1 antibody, RFT antibody, Cxxc3 antibody, CCDC11 antibody, methyl-CpG binding domain protein 1 antibody, MBD1 antibody, Mbd1 antibody
- Background
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Description: Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Gene: MBD1
- Molecular Weight
- 67 kDa
- Gene ID
- 4152
- UniProt
- Q9UIS9
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