MAFB antibody (C-Term)

Catalog No. ABIN6263052

Product Details anti-MAFB Antibody

Target: MAFB (Transcription Factor MafB (MAFB))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAFB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: MAFB Antibody detects endogenous levels of total MAFB.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MAFB, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for MAFB

Target: MAFB (Transcription Factor MafB (MAFB))

Alternative Name: MAFB (MAFB Products)

Synonyms: MAFB antibody, krml antibody, Maf-B antibody, XMafB antibody, kreisler antibody, MGC108453 antibody, valentino antibody, KRML antibody, MCTO antibody, Krml antibody, b-maf antibody, kr antibody, mafb antibody, val antibody, wu:fc22d11 antibody, wu:fj82a09 antibody, Kreisler antibody, Krml1 antibody, MAF bZIP transcription factor B antibody, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B antibody, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B S homeolog antibody, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba antibody, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) antibody, MAFB antibody, mafb antibody, mafb.S antibody, Mafb antibody, mafba antibody

Background:

Description: Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.

Gene: MAFB

Molecular Weight: 36 kDa

Gene ID: 9935

UniProt: Q9Y5Q3