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MAD2L2 antibody (Internal Region)

MAD2L2 Reactivity: Human, Mouse, Rat WB, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6263049
  • Target See all MAD2L2 Antibodies
    MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (MAD2L2))
    Binding Specificity
    • 15
    • 9
    • 4
    • 2
    • 1
    Internal Region
    Reactivity
    Human, Mouse, Rat
    Host
    • 40
    • 2
    Rabbit
    Clonality
    • 32
    • 10
    Polyclonal
    Conjugate
    • 17
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAD2L2 antibody is un-conjugated
    Application
    • 30
    • 14
    • 14
    • 13
    • 7
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    MAD2L2 Antibody detects endogenous levels of total MAD2L2.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human MAD2L2, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product MAD2L2 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (MAD2L2))
    Alternative Name
    MAD2L2 (MAD2L2 Products)
    Synonyms
    mad2b antibody, 2310033C13Rik antibody, MAD2B antibody, REV7 antibody, mad2B antibody, mad2l2-A antibody, xMAD2L2 antibody, POLZ2 antibody, mad2l2 antibody, zgc:110299 antibody, mitotic arrest deficient 2 like 2 antibody, MAD2 mitotic arrest deficient-like 2 antibody, mitotic arrest deficient 2 like 2 S homeolog antibody, MAD2 mitotic arrest deficient-like 2 (yeast) antibody, si:dkey-23c22.2 antibody, mad2l2 antibody, MAD2L2 antibody, Mad2l2 antibody, mad2l2.S antibody, si:dkey-23c22.2 antibody
    Background

    Description: Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.

    Gene: MAD2L2

    Molecular Weight
    24 kDa
    Gene ID
    10459
    UniProt
    Q9UI95
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