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LRP6 antibody (C-Term)

LRP6 Reactivity: Human, Mouse, Rat WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6263009
  • Target See all LRP6 Antibodies
    LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
    Binding Specificity
    • 22
    • 21
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 64
    • 45
    • 21
    • 1
    Human, Mouse, Rat
    Host
    • 60
    • 3
    • 1
    • 1
    Rabbit
    Clonality
    • 62
    • 3
    Polyclonal
    Conjugate
    • 18
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This LRP6 antibody is un-conjugated
    Application
    • 49
    • 26
    • 26
    • 17
    • 17
    • 15
    • 8
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Specificity
    LRP6 Antibody detects endogenous levels of total LRP6.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human LRP6, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product LRP6 Primary Antibody
  • Application Notes
    WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Zhu, Wang, Zhao, Zhang, Wu, Wang, Hu: "Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma." in: Oncotarget, Vol. 8, Issue 14, pp. 22825-22834, (2017) (PubMed).

  • Target
    LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
    Alternative Name
    LRP6 (LRP6 Products)
    Synonyms
    lrp6-A antibody, Xlrp6 antibody, adcad2 antibody, lrp6 antibody, LRP6 antibody, ADCAD2 antibody, C030016K15Rik antibody, Cd antibody, Gw antibody, LDL receptor related protein 6 antibody, LDL receptor related protein 6 L homeolog antibody, LDL receptor related protein 6 S homeolog antibody, low density lipoprotein receptor-related protein 6 antibody, low-density lipoprotein receptor-related protein 6 antibody, LRP6 antibody, lrp6.L antibody, lrp6.S antibody, lrp6 antibody, Lrp6 antibody, LOC590395 antibody
    Background

    Description: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

    Gene: LRP6

    Molecular Weight
    180 kDa
    Gene ID
    4040
    UniProt
    O75581
    Pathways
    WNT Signaling, Tube Formation
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