Kallikrein 7 antibody (Internal Region)

Catalog No. ABIN6262851

Product Details anti-Kallikrein 7 Antibody

Target: Kallikrein 7 (KLK7)

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Kallikrein 7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity: Kallikrein 7 Antibody detects endogenous levels of total Kallikrein 7.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Kallikrein 7, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Kallikrein 7

Target: Kallikrein 7 (KLK7)

Alternative Name: KLK7 (KLK7 Products)

Synonyms: Prss6 antibody, SCCE antibody, PRSS6 antibody, hK7 antibody, kallikrein related-peptidase 7 (chymotryptic, stratum corneum) antibody, kallikrein-related peptidase 7 antibody, kallikrein related peptidase 7 antibody, Klk7 antibody, KLK7 antibody

Background:

Description: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.

Gene: KLK7

Molecular Weight: 27kDa

Gene ID: 5650

UniProt: P49862

Pathways: Complement System