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IRG1 antibody (C-Term)

IRG1 Reactivity: Human ELISA, WB, ICC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6262659
  • Target See all IRG1 products
    IRG1 (Immunoresponsive Gene 1 (IRG1))
    Binding Specificity
    C-Term
    Reactivity
    • 12
    • 1
    Human
    Host
    • 12
    Rabbit
    Clonality
    • 12
    Polyclonal
    Conjugate
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IRG1 antibody is un-conjugated
    Application
    ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    IRG1 Antibody detects endogenous levels of total IRG1.
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human IRG1, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
  • Application Notes
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    IRG1 (Immunoresponsive Gene 1 (IRG1))
    Alternative Name
    ACOD1 (IRG1 Products)
    Synonyms
    CAD antibody, AI323667 antibody, aconitate decarboxylase 1 antibody, ACOD1 antibody, Acod1 antibody
    Background

    Description: Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells, ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.

    Gene: ACOD1

    Molecular Weight
    55 kDa
    Gene ID
    730249
    UniProt
    A6NK06
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