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CABLES1 antibody (C-Term)

CABLES1 Reactivity: Human, Mouse WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6262503
  • Target See all CABLES1 Antibodies
    CABLES1 (Cdk5 and Abl Enzyme Substrate 1 (CABLES1))
    Binding Specificity
    • 7
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 25
    • 18
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 23
    • 2
    Rabbit
    Clonality
    • 25
    Polyclonal
    Conjugate
    • 18
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CABLES1 antibody is un-conjugated
    Application
    • 18
    • 8
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    Ik3-1 Antibody detects endogenous levels of total Ik3-1.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human Ik3-1, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
  • Application Notes
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    CABLES1 (Cdk5 and Abl Enzyme Substrate 1 (CABLES1))
    Alternative Name
    CABLES1 (CABLES1 Products)
    Synonyms
    CABLES1 antibody, si:dkey-2p18.3 antibody, CABL1 antibody, CABLES antibody, HsT2563 antibody, IK3-1 antibody, Cables antibody, ik3-1 antibody, Cdk5 and Abl enzyme substrate 1 antibody, CDK5 and Abl enzyme substrate 1 antibody, CABLES1 antibody, cables1 antibody, CpipJ_CPIJ019832 antibody, Cables1 antibody
    Background

    Description: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).

    Gene: CABLES1

    Molecular Weight
    67 kDa
    Gene ID
    91768
    UniProt
    Q8TDN4
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