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IFT57 antibody (Internal Region)

IFT57 Reactivity: Human, Mouse, Rat, Dog WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6262481
  • Target See all IFT57 Antibodies
    IFT57 (Intraflagellar Transport 57 Homolog (IFT57))
    Binding Specificity
    • 15
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    Human, Mouse, Rat, Dog
    Host
    • 29
    • 4
    • 1
    Rabbit
    Clonality
    • 31
    • 3
    Polyclonal
    Conjugate
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IFT57 antibody is un-conjugated
    Application
    • 28
    • 13
    • 13
    • 10
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificity
    IFT57 Antibody detects endogenous levels of total IFT57.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human IFT57, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product IFT57 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    IFT57 (Intraflagellar Transport 57 Homolog (IFT57))
    Alternative Name
    IFT57 (IFT57 Products)
    Background

    Description: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator, however the relevance of such function remains unclear.

    Gene: IFT57

    Molecular Weight
    49 kDa
    Gene ID
    55081
    UniProt
    Q9NWB7
    Pathways
    Hedgehog Signaling, Positive Regulation of Endopeptidase Activity
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