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HUS1 antibody (Internal Region)

HUS1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6262423
  • Target See all HUS1 Antibodies
    HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))
    Binding Specificity
    • 15
    • 8
    • 7
    • 7
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    Human, Mouse, Rat
    Host
    • 62
    • 4
    Rabbit
    Clonality
    • 65
    • 1
    Polyclonal
    Conjugate
    • 23
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HUS1 antibody is un-conjugated
    Application
    • 31
    • 26
    • 13
    • 13
    • 9
    • 8
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    HUS1 Antibody detects endogenous levels of total HUS1.
    Predicted Reactivity
    Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human HUS1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product HUS1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))
    Alternative Name
    HUS1 (HUS1 Products)
    Synonyms
    hHUS1 antibody, mHus1 antibody, XHus1 antibody, hus1 antibody, HUS1 checkpoint clamp component antibody, checkpoint clamp complex protein Hus1 antibody, HUS1 checkpoint clamp component L homeolog antibody, HUS1 antibody, Hus1 antibody, hus1 antibody, hus1.L antibody
    Background

    Description: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.

    Gene: HUS1

    Molecular Weight
    31kDa
    Gene ID
    3364
    UniProt
    O60921
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