HLA-DMA antibody

Catalog No. ABIN6262285

Product Details anti-HLA-DMA Antibody

Target: HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HLA-DMA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: HLA-DMA Antibody detects endogenous levels of total HLA-DMA

Cross-Reactivity: Human, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human HLA-DMA

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000 IHC 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for HLA-DMA

Target: HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))

Alternative Name: HLA-DMA (HLA-DMA Products)

Synonyms: RT1.Ma antibody, RT1.DMa antibody, HLA-DMA antibody, H-2Ma antibody, H2-Ma antibody, D6S222E antibody, DMA antibody, HLADM antibody, RING6 antibody, RT1 class II, locus DMa antibody, SLA-DM alpha chain antibody, major histocompatibility complex, class II, DM alpha antibody, histocompatibility 2, class II, locus DMa antibody, RT1-DMa antibody, SLA-DMA antibody, DLA-DMA antibody, H2-DMa antibody, HLA-DMA antibody

Background:

Description: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.

Gene: HLA-DMA

Molecular Weight: 29 kDa

UniProt: P28067

Pathways: Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response