HCN2 antibody (Internal Region)

Catalog No. ABIN6262168

Product Details anti-HCN2 Antibody

Target: HCN2 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HCN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: HCN2 Antibody detects endogenous levels of total HCN2.

Predicted Reactivity: Pig,Bovine,Sheep,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human HCN2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for HCN2

Target: HCN2 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2))

Alternative Name: HCN2 (HCN2 Products)

Synonyms: HCN2 antibody, BCNG-2 antibody, BCNG2 antibody, HAC-1 antibody, HAC1 antibody, trls antibody, hyperpolarization activated cyclic nucleotide-gated potassium channel 2 antibody, hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 antibody, hyperpolarization-activated, cyclic nucleotide-gated K+ 2 antibody, LOC428335 antibody, HCN2 antibody, Hcn2 antibody

Background:

Description: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and  pH , acidic  pH shifts the activation to more negative voltages (By similarity).

Gene: HCN2

Molecular Weight: 96 kDa

Gene ID: 610

UniProt: Q9UL51