Hepcidin antibody (Internal Region)

Catalog No. ABIN6262147

Product Details anti-Hepcidin Antibody

Target: Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Hepcidin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity: HAMP Antibody detects endogenous levels of total HAMP.

Predicted Reactivity: Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human HAMP, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Hepcidin

Target: Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))

Alternative Name: HAMP (HAMP Products)

Synonyms: HEPC antibody, HFE2B antibody, LEAP1 antibody, PLTR antibody, Hepcidin antibody, Hamp1 antibody, Hepc antibody, Hepc1 antibody, HAMP antibody, hepcidin antibody, hamp1 antibody, hep1 antibody, hepcidin antimicrobial peptide antibody, hepcidin-like antibody, hepcidin-1 antibody, Ham percentage antibody, HAMP antibody, Hamp antibody, hamp antibody, LOC100135935 antibody, LOC106584587 antibody

Background:

Description: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005).

Gene: HAMP

Molecular Weight: 9kDa

Gene ID: 57817

UniProt: P81172

Pathways: Hormone Activity, Transition Metal Ion Homeostasis