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FOXP1 antibody (C-Term)

FOXP1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6261807
  • Target See all FOXP1 Antibodies
    FOXP1 (Forkhead Box P1 (FOXP1))
    Binding Specificity
    • 16
    • 14
    • 12
    • 8
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 75
    • 48
    • 25
    • 19
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 81
    • 12
    • 1
    Rabbit
    Clonality
    • 71
    • 22
    • 1
    Polyclonal
    Conjugate
    • 43
    • 8
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FOXP1 antibody is un-conjugated
    Application
    • 47
    • 38
    • 33
    • 31
    • 12
    • 7
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    FOXP1 Antibody detects endogenous levels of total FOXP1.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human FOXP1, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product FOXP1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    FOXP1 (Forkhead Box P1 (FOXP1))
    Alternative Name
    FOXP1 (FOXP1 Products)
    Synonyms
    12CC4 antibody, QRF1 antibody, hFKH1B antibody, 3110052D19Rik antibody, 4932443N09Rik antibody, AI461938 antibody, AW494214 antibody, foxp1 antibody, im:7139058 antibody, wu:fc83a06 antibody, FOXP1 antibody, MGC145686 antibody, 12cc4 antibody, fkh1b antibody, hspc215 antibody, qrf1 antibody, xlfoxp1 antibody, im:7146611 antibody, wu:fb97f01 antibody, zgc:154010 antibody, forkhead box P1 antibody, forkhead box P1b antibody, forkhead box P1 S homeolog antibody, forkhead box P1a antibody, FOXP1 antibody, Foxp1 antibody, foxp1b antibody, foxp1 antibody, foxp1.S antibody, foxp1a antibody
    Background

    Description: Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program, the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity, may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence, the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions, repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis, the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093).

    Gene: FOXP1

    Molecular Weight
    75kDa
    Gene ID
    27086
    UniProt
    Q9H334
    Pathways
    Chromatin Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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