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EYA2 antibody (Internal Region)

EYA2 Reactivity: Human, Rat WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6261629
  • Target See all EYA2 Antibodies
    EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))
    Binding Specificity
    • 15
    • 7
    • 6
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 41
    • 18
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Rat
    Host
    • 53
    • 3
    Rabbit
    Clonality
    • 54
    • 2
    Polyclonal
    Conjugate
    • 20
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This EYA2 antibody is un-conjugated
    Application
    • 43
    • 25
    • 13
    • 13
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    EYA2 Antibody detects endogenous levels of total EYA2.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human EYA2, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product EYA2 Primary Antibody
  • Application Notes
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))
    Alternative Name
    EYA2 (EYA2 Products)
    Synonyms
    EYA2 antibody, zgc:92279 antibody, eab1 antibody, Eab1 antibody, EAB1 antibody, EYA transcriptional coactivator and phosphatase 2 antibody, EYA2 antibody, eya2 antibody, Eya2 antibody
    Background

    Description: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2, in this it is functionally redundant with EYA1 (PubMed:12500905).

    Gene: EYA2

    Molecular Weight
    59 kDa
    Gene ID
    2139
    UniProt
    O00167
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