EXT1 antibody

Catalog No. ABIN6261628

Product Details anti-EXT1 Antibody

Target: EXT1 (Exostosin 1 (EXT1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: EXT1 Antibody detects endogenous levels of total EXT1

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human EXT1

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for EXT1

Target: EXT1 (Exostosin 1 (EXT1))

Alternative Name: EXT1 (EXT1 Products)

Synonyms: EXT antibody, LGCR antibody, LGS antibody, TRPS2 antibody, TTV antibody, AA409028 antibody, xext1 antibody, fd07d06 antibody, wu:fd07d06 antibody, exostosin glycosyltransferase 1 antibody, exostoses (multiple) 1 antibody, exostosin glycosyltransferase 1b antibody, exostosin like glycosyltransferase 1 antibody, exostosin glycosyltransferase 1 S homeolog antibody, exostosin glycosyltransferase 1a antibody, EXT1 antibody, Ext1 antibody, ext1b antibody, EXTL1 antibody, ext1.S antibody, ext1a antibody

Background:

Description: Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Gene: EXT1

Molecular Weight: 86kDa

Gene ID: 2131

UniProt: Q16394

Pathways: Glycosaminoglycan Metabolic Process