EHMT2 antibody (N-Term)

Catalog No. ABIN6261470

Product Details anti-EHMT2 Antibody

Target: EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EHMT2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: EHMT2 Antibody detects endogenous levels of total EHMT2.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human EHMT2, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for EHMT2

Target: EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))

Alternative Name: EHMT2 (EHMT2 Products)

Synonyms: BAT8 antibody, C6orf30 antibody, G9A antibody, GAT8 antibody, KMT1C antibody, NG36 antibody, T27C4.12 antibody, T27C4_12 antibody, DL3235W antibody, FCAALL.188 antibody, T18B16.120 antibody, T18B16_120 antibody, F9H3.13 antibody, F9H3_13 antibody, F9H3.7 antibody, F9H3_7 antibody, F9H3.9 antibody, F9H3_9 antibody, F9H3.6 antibody, F9H3_6 antibody, F13G24.40 antibody, T20K14.110 antibody, T20K14_110 antibody, MWD22.10 antibody, MWD22_10 antibody, MRB17.12 antibody, MRB17_12 antibody, MAF19.22 antibody, MAF19_22 antibody, Bat8 antibody, D17Ertd710e antibody, G9a antibody, Ng36 antibody, euchromatic histone lysine methyltransferase 2 antibody, ankyrin repeat-containing protein antibody, Ankyrin repeat family protein antibody, euchromatic histone lysine N-methyltransferase 2 antibody, EHMT2 antibody, ank1 antibody, IscW_ISCW006888 antibody, Arnit_2917 antibody, AT3G04470 antibody, AT4G14390 antibody, AT4G19150 antibody, AT4G03500 antibody, AT4G03450 antibody, AT4G03460 antibody, AT4G03440 antibody, PIA1 antibody, AT5G15500 antibody, AT5G51160 antibody, AT5G54620 antibody, ANK6 antibody, AT1G04780 antibody, AT1G62050 antibody, Ehmt2 antibody

Background:

Description: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.

Gene: EHMT2

Molecular Weight: 132kDa

Gene ID: 10919

UniProt: Q96KQ7