DOM3Z antibody (Internal Region)

Catalog No. ABIN6261355

Product Details anti-DOM3Z Antibody

Target: DOM3Z (Dom-3 Homolog Z (DOM3Z))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOM3Z antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: DOM3Z Antibody detects endogenous levels of total DOM3Z.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human DOM3Z, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for DOM3Z

Target: DOM3Z (Dom-3 Homolog Z (DOM3Z))

Alternative Name: DXO (DOM3Z Products)

Synonyms: ng6 antibody, dom3l antibody, DXO antibody, DOM3L antibody, NG6 antibody, RAI1 antibody, decapping exoribonuclease antibody, dom-3 homolog Z (C. elegans) antibody, decapping exoribonuclease L homeolog antibody, DXO antibody, DOM3Z antibody, dxo antibody, dxo.L antibody, Dxo antibody

Background:

Description: Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).

Gene: DXO

Molecular Weight: 45 kDa

Gene ID: 1797

UniProt: O77932