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DOCK7 antibody (N-Term)

DOCK7 Reactivity: Human, Rat, Mouse ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6261348
  • Target See all DOCK7 Antibodies
    DOCK7 (Dedicator of Cytokinesis 7 (DOCK7))
    Binding Specificity
    • 15
    • 5
    • 2
    • 2
    • 2
    N-Term
    Reactivity
    • 35
    • 16
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Rat, Mouse
    Host
    • 33
    • 2
    Rabbit
    Clonality
    • 35
    Polyclonal
    Conjugate
    • 10
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DOCK7 antibody is un-conjugated
    Application
    • 13
    • 13
    • 9
    • 7
    • 5
    • 3
    • 3
    • 1
    ELISA, Western Blotting (WB)
    Specificity
    DOCK7 Antibody detects endogenous levels of total DOCK7.
    Predicted Reactivity
    Pig,Bovine,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human DOCK7, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product DOCK7 Primary Antibody
  • Application Notes
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    DOCK7 (Dedicator of Cytokinesis 7 (DOCK7))
    Alternative Name
    DOCK7 (DOCK7 Products)
    Synonyms
    im:7145816 antibody, im:7157388 antibody, wu:fb93h07 antibody, ZIR2 antibody, 3110056M06Rik antibody, Gm430 antibody, m antibody, mKIAA1771 antibody, dedicator of cytokinesis 7 antibody, dedicator of cytokinesis protein 7 antibody, dedicator of cytokinesis 6 antibody, DOCK7 antibody, dock7 antibody, NAEGRDRAFT_56982 antibody, LOC100185115 antibody, dock6 antibody, Dock7 antibody
    Background

    Description: Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation, negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).

    Gene: DOCK7

    Molecular Weight
    242kDa
    Gene ID
    85440
    UniProt
    Q96N67
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