DOCK11 antibody (Internal Region)

Catalog No. ABIN6261346

Product Details anti-DOCK11 Antibody

Target: DOCK11 (Dedicator of Cytokinesis 11 (DOCK11))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOCK11 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: DOCK11 Antibody detects endogenous levels of total DOCK11.

Predicted Reactivity: Pig,Zebrafish,Bovine,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human DOCK11, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for DOCK11

Target: DOCK11 (Dedicator of Cytokinesis 11 (DOCK11))

Alternative Name: DOCK11 (DOCK11 Products)

Synonyms: ACG antibody, ZIZ2 antibody, bB128O4.1 antibody, 5033414A21Rik antibody, 8030476J24 antibody, Zizimin2 antibody, sph238 antibody, dedicator of cytokinesis 11 antibody, DOCK11 antibody, Dock11 antibody

Background:

Description: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42.

Gene: DOCK11

Molecular Weight: 238kDa

Gene ID: 139818

UniProt: Q5JSL3