Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

DNAJC3 antibody (C-Term)

DNAJC3 Reactivity: Human, Mouse, Rat ELISA, WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6261337
  • Target See all DNAJC3 Antibodies
    DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3))
    Binding Specificity
    • 15
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 24
    • 18
    • 16
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 37
    • 3
    Rabbit
    Clonality
    • 38
    • 2
    Polyclonal
    Conjugate
    • 12
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DNAJC3 antibody is un-conjugated
    Application
    • 14
    • 13
    • 13
    • 10
    • 4
    • 3
    • 3
    • 3
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
    Specificity
    DNAJC3 Antibody detects endogenous levels of total DNAJC3.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human DNAJC3, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product DNAJC3 Primary Antibody
  • Application Notes
    WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3))
    Alternative Name
    DNAJC3 (DNAJC3 Products)
    Synonyms
    ERdj6 antibody, HP58 antibody, P58 antibody, P58IPK antibody, PRKRI antibody, zgc:56356 antibody, zgc:77731 antibody, wu:fb64f06 antibody, DNAJC3 antibody, dnajc3 antibody, DDBDRAFT_0186884 antibody, DDBDRAFT_0233602 antibody, DDB_0186884 antibody, DDB_0233602 antibody, cg8286 antibody, AA408985 antibody, AU067833 antibody, Dnajc3a antibody, Dnajc3b antibody, Prkri antibody, mp58 antibody, p58 antibody, p58IPK antibody, fc17a06 antibody, prkri antibody, wu:fc17a06 antibody, DnaJ heat shock protein family (Hsp40) member C3 antibody, DnaJ (Hsp40) homolog, subfamily C, member 3a antibody, DNAJ heat shock N-terminal domain-containing protein antibody, DnaJ heat shock protein family (Hsp40) member C3 L homeolog antibody, DnaJ (Hsp40) homolog, subfamily C, member 3b antibody, DNAJC3 antibody, dnajc3a antibody, dnajc3 antibody, dnajc3.L antibody, Dnajc3 antibody, dnajc3b antibody
    Background

    Description: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.

    Gene: DNAJC3

    Molecular Weight
    54 kDa
    Gene ID
    5611
    UniProt
    Q13217
    Pathways
    ER-Nucleus Signaling
Support