Cyclin C antibody (C-Term)

Catalog No. ABIN6261144

Product Details anti-Cyclin C Antibody

Target: Cyclin C (CCNC)

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin C antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: Cyclin C Antibody detects endogenous levels of total Cyclin C.

Predicted Reactivity: Bovine,Horse,Sheep,Rabbit,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Cyclin C, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Cyclin C

Target: Cyclin C (CCNC)

Alternative Name: CCNC (CCNC Products)

Synonyms: CG1C_DROME antibody, CG7281 antibody, CYCC antibody, Cln3 antibody, Cyc-C antibody, DmcycC antibody, Dmel\\CG7281 antibody, SRB11 antibody, cycC antibody, cyclinC antibody, dTRAP33 antibody, fj11d06 antibody, wu:fj11d06 antibody, zgc:73078 antibody, Cyclin-C antibody, CycC antibody, AI451004 antibody, AU020987 antibody, CG1C antibody, Cyclin C antibody, cyclin C antibody, cyclin C L homeolog antibody, cyclin-C antibody, CycC antibody, ccnc antibody, CCNC antibody, Ccnc antibody, ccnc.L antibody, LOC5577815 antibody

Background:

Description: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Gene: CCNC

Molecular Weight: 33 kDa

Gene ID: 892

UniProt: P24863

Pathways: Cell Division Cycle, Regulation of Lipid Metabolism by PPARalpha