CNGA3 antibody (N-Term)

Catalog No. ABIN6260908

Product Details anti-CNGA3 Antibody

Target: CNGA3 (Cyclic Nucleotide Gated Channel alpha 3 (CNGA3))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNGA3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: CNGA3 Antibody detects endogenous levels of total CNGA3.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CNGA3, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CNGA3

Target: CNGA3 (Cyclic Nucleotide Gated Channel alpha 3 (CNGA3))

Alternative Name: CNGA3 (CNGA3 Products)

Synonyms: ACHM2 antibody, CCNC1 antibody, CCNCa antibody, CCNCalpha antibody, CNCG3 antibody, CNG3 antibody, CNGA3 antibody, cyclic nucleotide gated channel alpha 3 antibody, CNGA3 antibody, Cnga3 antibody

Background:

Description: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.

Gene: CNGA3

Molecular Weight: 79 kDa

Gene ID: 1261

UniProt: Q16281

Pathways: Phototransduction