CHAC1 antibody (Internal Region)
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- Target See all CHAC1 Antibodies
- CHAC1 (ChaC, Cation Transport Regulator Homolog 1 (CHAC1))
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Binding Specificity
- Internal Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CHAC1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- CHAC1 Antibody detects endogenous levels of total CHAC1.
- Predicted Reactivity
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human CHAC1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product CHAC1 Primary Antibody
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- Application Notes
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- CHAC1 (ChaC, Cation Transport Regulator Homolog 1 (CHAC1))
- Alternative Name
- CHAC1 (CHAC1 Products)
- Synonyms
- 1810008K03Rik antibody, RGD1307153 antibody, ChaC glutathione specific gamma-glutamylcyclotransferase 1 antibody, ChaC, cation transport regulator 1 antibody, ChaC glutathione-specific gamma-glutamylcyclotransferase 1 antibody, CHAC1 antibody, Chac1 antibody
- Background
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Description: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).
Gene: CHAC1
- Molecular Weight
- 29kDa
- Gene ID
- 79094
- UniProt
- Q9BUX1
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