Centriolin antibody

Catalog No. ABIN6260763

Product Details anti-Centriolin Antibody

Target: Centriolin (CNTRL)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Centriolin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity: CEP110 Antibody detects endogenous levels of total CEP110

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CEP110

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000 IHC 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for Centriolin

Target: Centriolin (CNTRL)

Alternative Name: CEP110 (CNTRL Products)

Synonyms: CEP1 antibody, CEP110 antibody, FAN antibody, bA165P4.1 antibody, Cep1 antibody, Cep110 antibody, 6720467O09Rik antibody, AA968343 antibody, Cntrl antibody, IB3/5 antibody, Ma2a8 antibody, b2b1468Clo antibody, centriolin antibody, CNTRL antibody, Cntrl antibody

Background:

Description: Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425).

Gene: CCP110

Molecular Weight: 113kDa

Gene ID: 9738

UniProt: O43303

Pathways: M Phase, SARS-CoV-2 Protein Interactome