CDK13 antibody (Internal Region)

Catalog No. ABIN6260604

Product Details anti-CDK13 Antibody

Target: CDK13 (Cyclin-Dependent Kinase 13 (CDK13))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK13 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: CD2L5 Antibody detects endogenous levels of total CD2L5.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CD2L5, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CDK13

Target: CDK13 (Cyclin-Dependent Kinase 13 (CDK13))

Alternative Name: CDK13 (CDK13 Products)

Synonyms: CDC2L5 antibody, cdc2l5 antibody, wu:fe16d10 antibody, wu:fi49c05 antibody, CDC2L antibody, CHED antibody, hCDK13 antibody, 2310015O17Rik antibody, Cdc2l5 antibody, cyclin dependent kinase 13 antibody, cyclin-dependent kinase 13 antibody, CDK13 antibody, cdk13 antibody, Cdk13 antibody

Background:

Description: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.

Gene: CDK13

Molecular Weight: 165 kDa

Gene ID: 8621

UniProt: Q14004