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CCDC99 antibody (C-Term)

CCDC99 Reactivity: Human, Mouse ELISA, WB, ICC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6260531
  • Target See all CCDC99 Antibodies
    CCDC99 (Coiled-Coil Domain Containing 99 (CCDC99))
    Binding Specificity
    • 15
    • 9
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 28
    • 16
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 41
    • 3
    Rabbit
    Clonality
    • 42
    • 2
    Polyclonal
    Conjugate
    • 14
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CCDC99 antibody is un-conjugated
    Application
    • 19
    • 17
    • 13
    • 13
    • 7
    • 4
    • 3
    • 2
    • 1
    ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    CCDC99 Antibody detects endogenous levels of total CCDC99.
    Predicted Reactivity
    Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human CCDC99, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product CCDC99 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    CCDC99 (Coiled-Coil Domain Containing 99 (CCDC99))
    Alternative Name
    SPDL1 (CCDC99 Products)
    Synonyms
    CCDC99 antibody, CG15415 antibody, Dmel\\CG15415 antibody, SPINDLY antibody, ccdc99 antibody, 1700018I02Rik antibody, 2600001J17Rik antibody, 2810049B11Rik antibody, AA409762 antibody, Ccdc99 antibody, RGD1306908 antibody, ccdc99-a antibody, ccdc99-b antibody, spdl1-a antibody, spdl1-b antibody, spdl1 antibody, spindle apparatus coiled-coil protein 1 antibody, CG15415 gene product from transcript CG15415-RB antibody, Tetratricopeptide repeat (TPR)-like superfamily protein antibody, spindle apparatus coiled-coil protein 1 L homeolog antibody, spindle apparatus coiled-coil protein 1 S homeolog antibody, SPDL1 antibody, Spindly antibody, SPY antibody, spdl1 antibody, Spdl1 antibody, spdl1.L antibody, spdl1.S antibody
    Background

    Description: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).

    Gene: SPDL1

    Molecular Weight
    70kDa
    Gene ID
    54908
    UniProt
    Q96EA4
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