BCCIP antibody (C-Term)

Catalog No. ABIN6260217

Product Details anti-BCCIP Antibody

Target: BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCCIP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: BCCIP Antibody detects endogenous levels of total BCCIP.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BCCIP, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for BCCIP

Target: BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))

Alternative Name: BCCIP (BCCIP Products)

Synonyms: zgc:110272 antibody, mp:zf637-1-000774 antibody, BCCIP antibody, DKFZp459K2416 antibody, MGC82792 antibody, tok-1 antibody, MGC89311 antibody, TOK-1 antibody, TOK1 antibody, 1110013J05Rik antibody, BRCA2 and CDKN1A interacting protein antibody, BRCA2 and CDKN1A interacting protein L homeolog antibody, BCCIP antibody, bccip antibody, bccip.L antibody, Bccip antibody

Background:

Description: During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).

Gene: BCCIP

Molecular Weight: 36 kDa

Gene ID: 56647

UniProt: Q9P287