ASPM antibody (Internal Region)

Catalog No. ABIN6260082

Product Details anti-ASPM Antibody

Target: ASPM (Asp (Abnormal Spindle) Homolog, Microcephaly Associated (ASPM))

Binding Specificity: Internal Region

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASPM antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting (WB)

Specificity: ASPM Antibody detects endogenous levels of total ASPM.

Predicted Reactivity: Bovine,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ASPM, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ASPM

Target: ASPM (Asp (Abnormal Spindle) Homolog, Microcephaly Associated (ASPM))

Alternative Name: ASPM (ASPM Products)

Synonyms: Calmbp1 antibody, ASPM antibody, ASP antibody, MCPH5 antibody, D330028K02Rik antibody, Sha1 antibody, abnormal spindle microtubule assembly antibody, asp (abnormal spindle)-like, microcephaly associated (Drosophila) antibody, Aspm antibody, ASPM antibody, aspm antibody

Background:

Description: Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.

Gene: ASPM

Molecular Weight: 410 kDa

Gene ID: 259266

UniProt: Q8IZT6