PYDC1 antibody

Catalog No. ABIN6260072

Product Details anti-PYDC1 Antibody

Target: PYDC1 (PYD (Pyrin Domain) Containing 1 (PYDC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PYDC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: ASC2 Antibody detects endogenous levels of total ASC2

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ASC2

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000 IHC 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for PYDC1

Target: PYDC1 (PYD (Pyrin Domain) Containing 1 (PYDC1))

Alternative Name: ASC2 (PYDC1 Products)

Synonyms: ASC2 antibody, POP1 antibody, PYC1 antibody, pyrin domain containing 1 antibody, PYDC1 antibody

Background:

Description: Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.

Gene: PYDC1

Molecular Weight: 10 kDa

Gene ID: 260434

UniProt: Q8WXC3