APOBEC3H antibody (C-Term)
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- Target See all APOBEC3H Antibodies
- APOBEC3H (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3H (APOBEC3H))
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Binding Specificity
- C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This APOBEC3H antibody is un-conjugated
- Application
- Western Blotting (WB), ELISA
- Specificity
- APOBEC3H Antibody detects endogenous levels of total APOBEC3H.
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human APOBEC3H, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product APOBEC3H Primary Antibody
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anti-Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3H (APOBEC3H) (AA 1-182) antibody
APOBEC3H Reactivity: Human WB, IF Host: Mouse Polyclonal unconjugated
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- Application Notes
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- APOBEC3H (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3H (APOBEC3H))
- Alternative Name
- APOBEC3H (APOBEC3H Products)
- Synonyms
- A3H antibody, ARP10 antibody, APOBEC3A antibody, apolipoprotein B mRNA editing enzyme catalytic subunit 3H antibody, APOBEC3H antibody
- Background
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Description: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
Gene: APOBEC3H
- Molecular Weight
- 24 kDa
- Gene ID
- 164668
- UniProt
- Q6NTF7
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