TADA2L antibody

Catalog No. ABIN6259764

Product Details anti-TADA2L Antibody

Target: TADA2L (TADA2A) (Transcriptional Adaptor 2A (TADA2A))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TADA2L antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: ADA2L antibody detects endogenous levels of total ADA2L

Cross-Reactivity: Human, Monkey, Mouse (Murine), Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ADA2L

Isotype: IgG

Application Details

Application Notes: WB: 1:500~1:3000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for TADA2L

Target: TADA2L (TADA2A) (Transcriptional Adaptor 2A (TADA2A))

Alternative Name: ADA2L (TADA2A Products)

Synonyms: MGC81519 antibody, TADA2A antibody, TADA2L antibody, ADA2 antibody, ADA2A antibody, hADA2 antibody, AV319371 antibody, D030022J10Rik antibody, Tada2l antibody, tada2l antibody, zgc:154057 antibody, transcriptional adaptor 2A L homeolog antibody, transcriptional adaptor 2A antibody, tada2a.L antibody, TADA2A antibody, Tada2a antibody, tada2a antibody

Background:

Description: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376).

Gene: TADA2A

Molecular Weight: 47kDa

Gene ID: 6871

UniProt: O75478

Pathways: Chromatin Binding