MYBL1 antibody (Internal Region)

Catalog No. ABIN6259660

Product Details anti-MYBL1 Antibody

Target: MYBL1 (Myb-Like Protein 1 (MYBL1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYBL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: A-Myb Antibody detects endogenous levels of total A-Myb.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human A-Myb, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for MYBL1

Target: MYBL1 (Myb-Like Protein 1 (MYBL1))

Alternative Name: MYBL1 (MYBL1 Products)

Synonyms: A-myb antibody, G1-419-6 antibody, repro9 antibody, AMYB antibody, xamyb antibody, A-MYB antibody, MYBL antibody, myeloblastosis oncogene-like 1 antibody, MYB proto-oncogene like 1 antibody, MYB proto-oncogene like 1 L homeolog antibody, Mybl1 antibody, mybl1.L antibody, MYBL1 antibody

Background:

Description: Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity).

Gene: MYBL1

Molecular Weight: 85kDa

Gene ID: 4603

UniProt: P10243

Pathways: Cell Division Cycle, Chromatin Binding