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YOD1 antibody (Internal Region)

YOD1 Reactivity: Human WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6259576
  • Target See all YOD1 Antibodies
    YOD1 (Ubiquitin Thioesterase OTU1 (YOD1))
    Binding Specificity
    • 9
    • 8
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 34
    • 9
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Host
    • 34
    Rabbit
    Clonality
    • 34
    Polyclonal
    Conjugate
    • 14
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This YOD1 antibody is un-conjugated
    Application
    • 23
    • 18
    • 14
    • 13
    • 5
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    YOD1 Antibody detects endogenous levels of total YOD1.
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human YOD1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product YOD1 Primary Antibody
  • Application Notes
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    YOD1 (Ubiquitin Thioesterase OTU1 (YOD1))
    Alternative Name
    YOD1 (YOD1 Products)
    Synonyms
    DUBA8 antibody, OTUD2 antibody, PRO0907 antibody, hshin7 antibody, wu:fe01a10 antibody, zgc:112182 antibody, 9930028C20Rik antibody, Hshin7 antibody, YOD1 deubiquitinase antibody, YOD1 deubiquitinase L homeolog antibody, YOD1 antibody, Yod1 antibody, yod1.L antibody, yod1 antibody
    Background

    Description: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622).

    Gene: YOD1

    Molecular Weight
    35 kDa
    Gene ID
    55432
    UniProt
    Q5VVQ6
    Pathways
    ER-Nucleus Signaling
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