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Shugoshin antibody (N-Term)

SGOL1 Reactivity: Human, Mouse, Rat ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6259304
  • Target See all Shugoshin (SGOL1) Antibodies
    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
    Binding Specificity
    • 10
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 44
    • 4
    • 4
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 42
    • 3
    Rabbit
    Clonality
    • 43
    • 2
    Polyclonal
    Conjugate
    • 24
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Shugoshin antibody is un-conjugated
    Application
    • 30
    • 26
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Specificity
    SGOL1 Antibody detects endogenous levels of total SGOL1.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human SGOL1, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product SGOL1 Primary Antibody
  • Application Notes
    WB 1:500-1:1000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
    Alternative Name
    SGO1 (SGOL1 Products)
    Synonyms
    sgo1 antibody, NY-BR-85 antibody, SGO antibody, Sgo1 antibody, 3300001M08Rik antibody, C81037 antibody, shugoshin 1 antibody, shugoshin centromeric cohesion 1 antibody, shugoshin 1 L homeolog antibody, Sgo1 antibody, sgo1 antibody, sgo1.L antibody, SGO1 antibody
    Background

    Description: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.

    Gene: SGO1

    Molecular Weight
    64 kDa
    Gene ID
    151648
    UniProt
    Q5FBB7
    Pathways
    Maintenance of Protein Location
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