TOPORS antibody (C-Term)
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- Target See all TOPORS Antibodies
- TOPORS (Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS))
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Binding Specificity
- C-Term
- Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TOPORS antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificity
- TOPRS Antibody detects endogenous levels of total TOPRS.
- Predicted Reactivity
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human TOPRS, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product TOPORS Primary Antibody
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- TOPORS (Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS))
- Alternative Name
- TOPORS (TOPORS Products)
- Synonyms
- CG15104 antibody, Dmel\\CG15104 antibody, TOPORS antibody, dTopors antibody, dtopors antibody, fi75f04 antibody, wu:fi75f04 antibody, AW105885 antibody, LUN antibody, TP53BPL antibody, p53BP3/LUN antibody, P53BP3 antibody, RP31 antibody, Topoisomerase I-interacting protein antibody, TOP1 binding arginine/serine rich protein antibody, topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase antibody, topoisomerase I binding, arginine/serine-rich b antibody, topoisomerase I binding, arginine/serine-rich antibody, Topors antibody, TOPORS antibody, topors antibody, toporsb antibody
- Background
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Description: Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
Gene: TOPORS
- Gene ID
- 10210
- UniProt
- Q9NS56
- Pathways
- Maintenance of Protein Location
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