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SUV39H2 antibody (Internal Region)

SUV39H2 Reactivity: Human, Mouse WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6259202
  • Target See all SUV39H2 Antibodies
    SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))
    Binding Specificity
    • 13
    • 10
    • 8
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 66
    • 28
    • 22
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 64
    • 2
    • 1
    Rabbit
    Clonality
    • 59
    • 8
    Polyclonal
    Conjugate
    • 33
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This SUV39H2 antibody is un-conjugated
    Application
    • 51
    • 37
    • 21
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    SUV39H2 Antibody detects endogenous levels of total SUV39H2.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human SUV39H2, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product SUV39H2 Primary Antibody
  • Application Notes
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))
    Alternative Name
    SUV39H2 (SUV39H2 Products)
    Synonyms
    KMT1B antibody, 4930507K23Rik antibody, AA536750 antibody, D030054H19Rik antibody, D2Ertd544e antibody, SUV39H2 antibody, kmt1b antibody, suppressor of variegation 3-9 homolog 2 antibody, suppressor of variegation 3-9 homolog 2 (Drosophila) antibody, suppressor of variegation 3-9 homolog 2 L homeolog antibody, SUV39H2 antibody, Suv39h2 antibody, suv39h2 antibody, suv39h2.L antibody
    Background

    Description: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

    Gene: SUV39H2

    Molecular Weight
    46 kDa
    Gene ID
    79723
    UniProt
    Q9H5I1
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